Paternal Nutrition and Daughter's Risk

Scripture of the Day:

Luke 4:40

Now when the sun was setting, all they had sick with divers diseases  brought them unto him, and he laid his hands on them and healed them.

I'm finding many interesting things about breast cancer and what researchers think. Some of it is quite frightening. I'm not sure I'm in with some of it. I've read that they blame it on smoking, obesity, heredity, and environmental. Now this article about paternal influences. Sadly, what it boils down to is that there is no way to avoid the possibility of breast cancer or any other cancer. The link to this article is at the bottom of the page.

Paternal programming of breast cancer risk in daughters...

Camile Castilho Fontelles,

Luiza Nicolosi Guido,

Mariana Papaléo Rosim,

Fábia de Oliveira Andrade,

Lu Jin,

Jessica Inchauspe,

Vanessa Cardoso Pires,

Inar Alves de Castro,

Leena Hilakivi-Clarke,

Sonia de Assis and 

Thomas Prates Ong

Background

Although males contribute half of the embryo’s genome, only recently has interest begun to be directed toward the potential impact of paternal experiences on the health of offspring. While there is evidence that paternal malnutrition may increase offspring susceptibility to metabolic diseases, the influence of paternal factors on a daughter’s breast cancer risk has been examined in few studies..

Methods

Male Sprague-Dawley rats were fed, before and during puberty, either a lard-based (high in saturated fats) or a corn oil-based (high in n-6 polyunsaturated fats) high-fat diet (60 % of fat-derived energy). Control animals were fed an AIN-93G control diet (16 % of fat-derived energy). Their 50-day-old female offspring fed only a commercial diet were subjected to the classical model of mammary carcinogenesis based on 7,12-dimethylbenz[a]anthracene initiation, and mammary tumor development was evaluated. Sperm cells and mammary gland tissue were subjected to cellular and molecular analysis.

Results

Compared with female offspring of control diet-fed male rats, offspring of lard-fed male rats did not differ in tumor latency, growth, or multiplicity. However, female offspring of lard-fed male rats had increased elongation of the mammary epithelial tree, number of terminal end buds, and tumor incidence compared with both female offspring of control diet-fed and corn oil-fed male rats. Compared with female offspring of control diet-fed male rats, female offspring of corn oil-fed male rats showed decreased tumor growth but no difference regarding tumor incidence, latency, or multiplicity. Additionally, female offspring of corn oil-fed male rats had longer tumor latency as well as decreased tumor growth and multiplicity compared with female offspring of lard-fed male rats. Paternal consumption of animal- or plant-based high-fat diets elicited opposing effects, with lard rich in saturated fatty acids increasing breast cancer risk in offspring and corn oil rich in n-6 polyunsaturated fatty acids decreasing it. These effects could be linked to alterations in microRNA expression in fathers’ sperm and their daughters’ mammary glands, and to modifications in breast cancer-related protein expression in this tissue.

Paternal Nutrition and Daughter's Risk

If you are making this journey as I am, may God bless you with His healing touch. I know He loves you.